I think Retired and Sidestreamer are spot on. Retired notes the power of amendment, and Sidestreamer infers that Article IV Section 4, Clause 1 is a subset of the Constitution, not the guiding spirit or force of it. The guiding forces in my opinion are the Preamble, Amendment I and Amendment XIV, and, of course, the Supreme Court (Article III) that is given "original jurisdiction" on matters constitutional.
And while it doesn't normally get the attention it deserves, don't forget Amendment IX. Nothing gives us a hint of what was envisioned better than the reservation of those unenumerated rights to the People.