I think the websites and advertisers who insist on using ads that irritate users are just shooting themselves in the ass. I’ve read articles by website owners who think they can bully users into watching their horrible ads. They think they're right and the visitors using Ad Block are wrong. Period. And other websites think their visitors love their sites so much that they’ll tolerate any crappy ad they want to display. In any case, chasing away visitors doesn't sound like a winning strategy.
In the real world, advertisers work hard and long to find ways to produce ads that are attractive to potential customers. The last thing they want to do is irritate prospects with awful ads.
As another poster said, the same content can often be found at other sites. When I hit a website that whines about my using an Ad Blocker, I just head on down the road to another site. Usually I’ll have a page of search results in another tab, so similar content is just a click away.
Or, you can turn your Ad Blocker off, momentarily, as another poster said.