In a major technological advance, Australian scientists have fully synthesized all 16 chromosomes of the yeast saccharomyces Cerevisiae.
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Original journal publication:
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Scientists Just Achieved a Major Milestone in Creating Synthetic Life
After more than a decade of work, researchers have reached a major milestone in their efforts to re-engineer life in the lab, putting together the final chromosome in a synthetic yeast (Saccharomyces cerevisiae) genome.

Original journal publication:

Construction and iterative redesign of synXVI a 903 kb synthetic Saccharomyces cerevisiae chromosome - Nature Communications
The Sc2.0 project involved synthesis and debugging of 16 chromosomes, and a tRNA neochromosome. Here the authors descript the SynXVI project, accompanied by an analysis of how similar projects could operate with hindsight and newly available technologies, and lessons learned from Sc2.0.
