Scientists Find Clues to Aging in a Red Wine Ingredient’s Role in Activating a Protei

Discussion in 'Health and Lifestyle' started by Neubarth, Nov 27, 2008.

  1. Neubarth
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    Neubarth At the Ballpark July 30th

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    Scientists Find Clues to Aging in a Red Wine Ingredient’s Role in Activating a Protein

    The New York Times
    2008-11-27

    A new insight into the reason for aging has been gained by scientists trying to understand how resveratrol, a minor ingredient of red wine, improves the health and lifespan of laboratory mice. They believe that the integrity of chromosomes is compromised as people age, and that resveratrol works by activating a protein known as sirtuin that restores the chromosomes to health.

    The finding, published online Wednesday in the journal Cell, is from a group led by David Sinclair of the Harvard Medical School. It is part of a growing effort by biologists to understand the sirtuins and other powerful agents that control the settings on the living cell’s metabolism, like its handling of fats and response to insulin.

    Researchers are just beginning to figure out how these agents work and how to manipulate them, hoping that they can develop drugs to enhance resistance to disease and to retard aging.

    Sirtris, a company Dr. Sinclair helped found, has developed a number of chemicals that mimic resveratrol and are potentially more suitable as drugs since they activate sirtuin at much lower doses than resveratrol. This month, one of these chemicals was reported in the journal Cell Metabolism to protect mice on fatty diets from getting obese and to enhance their endurance in treadmills, just as resveratrol does.

    Though the sirtuin field holds considerable promise, the dust has far from settled. Resveratrol is a powerful agent with many different effects, only some of which are exerted through sirtuin. So drugs that activate sirtuin may not be as splendid a tonic for people as resveratrol certainly seems to be for mice.

    The new finding concerns maintenance of the chromosomes, the giant molecules of DNA that make up the genome.

    Each cell has six feet of DNA packed into its nucleus, carrying the 20,000 or so genetic instructions needed to operate the human body. Each cell must provide instant access to the handful of these genes needed by its cell type, but also keep the rest firmly switched off to avoid chaos.

    Sirtuin’s normal role is to help gag all the genes that a cell needs to keep suppressed. It does so by keeping the chromatin, the stuff that wraps around the DNA, packed so tightly that the cell cannot get access to the underlying genes.

    But sirtuin has another critical role, one that is triggered by emergencies like a break in both DNA strands of a chromosome. After a double strand break, sirtuin rushes to the site to help knit the two parts of the chromosome back together. But in this salvage operation, it leaves its post, and the genes it was repressing are liable to come back into action, causing mayhem.

    This, Dr. Sinclair and his colleagues suggest, may be a fundamental cause of aging in mice and probably people, too.

    The gene-gagging role of sirtuin was discovered in the 1980s by biologists studying yeast, a standard laboratory organism. Dr. Sinclair and Leonard Guarente of the Massachusetts Institute of Technology found in 1997 that sirtuin could also repair a certain kind of genomic damage in yeast, and in doing so extended the yeast cell’s lifespan. But this particular kind of damage does not occur in mammalian cells, raising the puzzle of why extra sirtuin should be good for them.

    Dr. Sinclair’s new report, if verified, resolves this problem by showing that sirtuin has retained its genomic repair role in higher organisms but that the repair is focused on a different kind of genomic damage — that of breaks in a chromosome.

    These experiments “elegantly demonstrate” that sirtuin works in much the same way in mammals as in yeast, Dr. Jan Vijg of the Albert Einstein College of Medicine wrote in a commentary in Cell. The question now is whether sirtuin is a pro-longevity factor in mammals, he said in an e-mail message.

    Ronald Evans, a biologist at the Salk Institute, said the new report was provocative but did not prove the case that the relocation of sirtuin was a cause of aging. Tests with mice genetically engineered to lack the sirtuin gene could show if the mice suffered from premature aging, as Dr. Sinclair’s idea would predict.

    Dr. Sinclair said he agreed that the case for sirtuin’s role in aging had not been proved. “We are careful not to say this is the cause of aging, but based on everything we know it’s not a bad hypothesis,” he said.

    It would be nice to test aging in mice that lack the sirtuin gene, as Dr. Evans proposed, but they die too young, Dr. Sinclair said.

    Dr. Sinclair has been taking large daily doses of resveratrol since he and others discovered five years ago that it activated sirtuin. “I’m still taking it, and I feel great,” he said, “but it’s too early to say if I’m young for my age.”
     
  2. pegwinn
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    pegwinn Top of the Food Chain

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    I thought I heard on the radio that someone was attempting to synthesize this and make it into an additive to other beverages. Can't find a link anywhere though. Since I am middle aged, could be that it is half-heimers.

    Would be a great thing though.
     
  3. jeffberg
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    jeffberg Rookie

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    Resveratrol can help you to lead a long and healthy life so says Dr. Oz.
    Red wine alone does not supply enough resveratrol to achieve the
    full range of benefits because one glass of red wine has only about
    1mg of resveratrol and you need about 250mg/day. You need to take
    high potency resveratrol supplements to achieve the results documented
    in scientific studies.Resveratrol Supplements can also help you control
    your weight naturally by increasing energy, reducing cravings, and limiting
    your appetite.According to Wikipedia, Consumer Lab, an independent dietary
    supplement and over the counter products evaluation organization,
    published a report on 13 November 2007 on the popular resveratrol
    supplements. The organization reported that there exists a wide range
    in quality, dose, and price among the 13 resveratrol products
    evaluated. The actual amount of resveratrol contained in the
    different brands range from 2.2mg for Revatrol, which claimed to have
    400mg of "Red Wine Grape Complex", to 500mg for Biotivia.com Transmax,
    which is consistent with the amount claimed on the product's label.
    Prices per 100mg of resveratrol ranged from less than $.30 for
    products made by Biotivia.com, jarrow, and country life, to a high of
    $45.27 for the Revatrol brand.
     
  4. random3434
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    random3434 Senior Member

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    I think I was just telling edict that I wish I could develop a taste for red wine, now I want to even more!
     
  5. Annie
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    Annie Diamond Member

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    I raise my glass of Merlot to you! LOL!
     
  6. William Joyce
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    William Joyce Chemotherapy for PC

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    Man, I love good news about booze.
     
  7. Toro
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    Toro Diamond Member

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    ANOTHER reason to drink red wine. Woo! Hoo!
     
  8. Southpaw
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    Southpaw Member

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    Red wine is a gift from God.

    The only white that I find even partially palpable is Cakebread Cellars but it's rather pricey.
     

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