New Drug to Tackle Body Fat Problems

Discussion in 'Science and Technology' started by Matthew, Apr 28, 2012.

  1. Matthew
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    Matthew Blue dog all the way!

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    New Drug to Tackle Body Fat Problems


    ScienceDaily (Apr. 27, 2012) — Medical researchers at the University of Sheffield have defined the structure of a key part of the human obesity receptor- an essential factor in the regulation of body fat- which could help provide new treatments for the complications of obesity and anorexia.


    This major advance in research, published in the journal Structure, will greatly enhance the ability to generate drugs which can both block and stimulate the receptor for the obesity hormone leptin. This could have life-changing effects on people suffering from the complications of obesity and malnutrition.

    Researchers have solved the challenging crystal structure of the leptin-binding domain of the obesity receptor using state of the art X-ray crystallography, helping them to work out how to block or stimulate the receptor. Leptin, the obesity hormone, is produced by fat and excess leptin predisposes overweight people to conditions such as multiple sclerosis, cancer and heart disease whilst a deficiency in leptin, as occurs in malnutrition, results in infertility and immunodeficiency.

    Blocking the receptor, and therefore the excessive actions of leptin, could prevent the complications of obesity and stimulating the receptor may improve fertility and the immune response.

    Professor Richard Ross, Professor of Endocrinology at the University of Sheffield said: "This pioneering research gives us the potential to generate new drugs that could treat conditions and diseases associated with obesity such as Multiple Sclerosis, diabetes and cardiovascular disease.

    "Modulating the actions of the obesity receptor provides a novel approach to the treatment of conditions associated with both obesity and anorexia and has the potential to make a massive difference to millions of people whose quality of life and health is hindered by obesity or malnutrition."

    Controlling appetite is a fundamental basic physiological drive which in turn is connected to many other aspects of physiology, in particular fertility and the immune response.

    Professor Pete Artymiuk, from the University of Sheffield´s Department of Molecular Biology and Biotechnology, said: "The human obesity receptor binds the hormone leptin and together they play a key role in regulating appetite, fertility, and immunity.
    New drug to tackle body fat problems
     
    Last edited: Apr 28, 2012
  2. Not2BSubjugated
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    Not2BSubjugated Callous Individualist

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    Why do they keep trying to reinvent the wheel on this one? We already have methamphetamine for weight loss and it works -fabulously-
     
  3. waltky
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    waltky Wise ol' monkey Supporting Member

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    Granny don't wanna be usin' her tax dollars fer Uncle Ferd's g/f's...
    :eusa_eh:
    New Study: US Obesity Levels Could Reach 42 Percent by 2030
    May 08, 2012 - A new forecast for the United States suggests that 42 percent adult Americans could be obese and 11 percent severely obese by the year 2030.
     
  4. waltky
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    waltky Wise ol' monkey Supporting Member

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    Granny gonna start puttin' pepper onna Uncle Ferd's g/f's meals when dey eat with us...
    :eusa_shifty:
    Black pepper fights formation of fat cells
    May 7,`12 (UPI) -- Researchers in South Korea say they are unlocking the secret to why black pepper fights fat.
    See also:

    Spices reduce triglyceride response
    Aug. 11,`12 (UPI) -- Adding spices to a high-fat meal reduces triglyceride response by about 30 percent, compared to a similar meal with no added spices, U.S. researchers say.
     
  5. Douger
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    Douger BANNED

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    In short. Don't eat like uh murkin.
    When I escaped that shithole I was 250. Now I'm 190.
    Time to make some Gallo Pinto !
     
  6. waltky
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    waltky Wise ol' monkey Supporting Member

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    Granny gonna invest in Arena stock an' give free samples to Uncle Ferd's g/f's...
    :tongue:
    US approves first obesity drug in 13 years
    27 June`12 - US regulators on Wednesday approved the first drug to treat obesity in 13 years, a drug called lorcaserin, marketed as Belviq and made by Arena Pharmaceuticals.
     
  7. waltky
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    waltky Wise ol' monkey Supporting Member

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    No longer is a fat baby a healthy baby...
    :eusa_eh:
    Severely obese children's hearts already in danger
    23 July 2012 - Severely obese children are putting their heart at danger even while they are still in primary school, according to a Dutch study.
     
  8. there4eyeM
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    there4eyeM unlicensed metaphysician

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    A drug to stop obesity? So, these people will still be able to eat too much (while others starve), and not get fat?
    Great!
    Talk about personal responsibility.
    New discovery to prevent obesity - STOP EATING!
     
  9. Matthew
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    Matthew Blue dog all the way!

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    Maybe if those starving third world countries worked to educate their populations toward learning modern farming...Well, maybe they would eat to the same. Ever thought of that? The concept must be over most of this worlds intelligence level.:eusa_shhh:

    Scotty beam me up!
     
    Last edited: Jul 24, 2012
  10. waltky
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    waltky Wise ol' monkey Supporting Member

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    Gallstone risk to obesity for teens...
    :eusa_eh:
    Gallstone risk 'higher among obese teenagers'
    24 August 2012 - Teenagers who are overweight or obese are much more likely to develop gallstones, compared with peers of a healthy weight, US research suggests.
     

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