If you are older a little sperm a day might help

[egp320i]

Spermadine that is!

It's derived from fermented wheat germ

I asked grok........
Yes, spermidine does help with autophagy! There’s solid evidence from multiple studies showing that spermidine promotes autophagy, a crucial cellular process where cells break down and recycle their own damaged or unnecessary components. This "self-cleaning" mechanism is linked to improved cellular health, longevity, and protection against age-related diseases.
Here’s how it works and what the research says:

1. Mechanism: Spermidine induces autophagy by influencing key molecular pathways. It inhibits enzymes like acetyltransferases (e.g., EP300), which normally suppress autophagy, and it upregulates genes like ATG (autophagy-related genes) that drive the process. This leads to the formation of autophagosomes—little cellular "garbage bags"—that engulf and degrade junk inside the cell.
2. Evidence in Model Organisms: Studies in yeast, worms, flies, and mice consistently show that spermidine supplementation extends lifespan and enhances autophagy. For instance, a landmark 2009 study in Nature Cell Biology demonstrated that spermidine increased autophagy in these organisms, linking it to longevity. In mice, spermidine has been shown to reduce age-related oxidative stress and improve heart and brain function, partly through autophagic cleanup.
3. Human Relevance: While most hard data comes from lab models, there’s growing evidence in human cells and some indirect clinical hints. Research on cultured human cells (like fibroblasts) shows spermidine triggers autophagy similarly to what’s seen in animals. A 2018 study in Nature Medicine also found that higher dietary spermidine intake (from foods like aged cheese, soybeans, or mushrooms) correlated with lower cardiovascular mortality in humans, potentially tied to autophagy’s protective effects.
4. Benefits: By boosting autophagy, spermidine may help clear out damaged proteins and organelles, reducing cellular stress and inflammation. This could slow aging processes, protect against neurodegenerative diseases (like Alzheimer’s), and improve metabolic health.
5. Limits: The exact dose and long-term effects in humans aren’t fully nailed down yet. Most studies use supplements in controlled settings, and while dietary spermidine is safe (it’s naturally in many foods), megadoses via supplements might have unknown risks.

In short, yes, spermidine reliably promotes autophagy across various species, with promising signs it does the same in humans. It’s one of its best-documented effects and a big reason it’s studied for anti-aging potential. If you’re curious about boosting autophagy naturally, eating spermidine-rich foods is a practical start, though the science is still refining how much you’d need for big benefits!


I dug into this awhile back, I don't think I need it yet but my mom who will be 80 soon has been taking it and she swears she feels better taking it

it's not that expensive and it likely won't hurt

not any endorsement, just randomly picked one on amazon, company is from WY, likely good stuff, a smaller company