Cure for Diabetes on Horizon NewsMax Health January 6, 2007 Diabetics may soon see a cure for their debilitating, life-threatening disease. Researchers from the Hospital for Sick Children in Toronto found that mice given injections of capsaicin, the active ingredient in hot chili peppers, cured mice of Type 1 diabetes almost immediately. The results astonished even the scientists who labeled their discovery as the biggest shock of our lives. Their findings indicate that diabetes is not a disease of the immune system, as has long been thought, but is a disease of the nervous system caused by faulty pain nerves in the pancreas. Immunologist Dr. Hans Michael Dosch and pain expert Dr. Michael Salter had noticed that the islet cells in diabetics were surrounded by massive numbers of pain nerves; they further noted that these nerves sent signals to the brain that the pancreatic tissue was injured, and believed that malfunctioning pain neurons in the pancreas could be the culprit. As a test, they injected mice that had Type 1 diabetes with capsaicin in order to kill the pain nerves in the pancreas. Almost immediately, the islet cells in the mice began producing insulin. We had the shock of our lives, said Dr. Dosch. Ive never seen anything like it. In my career, this is unique. I couldnt believe it, said Dr. Michael Salter, one of the scientists involved in the studies and a pain expert at the Hospital for Sick Children. Mice with diabetes suddenly didnt have diabetes anymore. Dosch and Salter later found that a single injection cured some mice for up to four months. They also found the treatment helped limit the insulin resistance that is characteristic of Type 2 diabetes. The two doctors hope to complete human trials within the next year.