COVID-19’s Biological Politics

[badger2]

In other words, by paying with their identity to read the Medscape article, the prisoners are each identified. This indeed links to the D.A.R., who are known to surveil potential “subversives” in Florida. It would look much too homosexual were the S.A.R. caught doing it in peacetime. The new nazi-style smokeless book-burnings have this modus operandi whereby the book is always on fire in the crematorium, though never consumed. When the prisoner tries to touch it, something happens, akin to Narcissus’s reflection in the pool, or a cactus.

 

[badger2]

To keep his credibility, Fauci must speak science by generalities. We’ve yet to hear him specifically point to the country of origin of these mutations of concern, lest it’s to warp the scientific process by splitting hosts, as he did for the N501Y mutation. In fact, the one he confused in his video, D614G, arose within a week apart in humans both in China and Germany. Duh.

On 11 Jan 2020 we posted the Brazil-Japanese E484K mutation, followed by Stuartbirdan on 14 Jan 2020.

#215 11 Jan 2020 E484K

COVID-19’s Biological Politics

Biological politics of statins link to Bolsonaro’s declaration of having antibodies against COVID-19. It is unknown whether statins assist, as in vaccines, in producing antibodies to C-19. However, other antibodies come into view as linking to why some people cannot tolerate cholesterol-lowering...

www.usmessageboard.com

#128,083 14 Jan 2020 E484K

https://www.usmessageboard.com/threads/keeping-amerrica-great-again.806764/page-6405#post-26342294

 

[badger2]

https://www.usmessageboard.com/threads/keeping-america-great-again.806764/page-6405#post-26342294

 

[badger2]

On 14 Jan, above, Stuartbirdan says E484K is from a Brazilian study though provides no citation. The study we now report on for the E484K mutation is from:

1. Fondazione Toscana, Siena, Italy
2. VisMederi, Siena, Italy
3. Dept. of Chemistry and Biochemistry, U. of California, San Diego, La Jolla, USA
4. Imperial College, London, UK
5. Dept. of Molecular Biosciences, U. of Texas, Austin

SARS-CoV-2 escape in vitro from a highly neutralizing COVID-19 convalescent plasma - PubMed

Three mutations allowed SARS-CoV-2 to evade the polyclonal antibody response of a highly neutralizing COVID-19 convalescent plasma.

www.ncbi.nlm.nih.gov

 

[badger2]

Glycans mentioned for the E484K mutation will link ebola- And HIV-1-neutralizing banana lectin, which has already been reported at USMB for the Tom Cairns ebola story, with Novaya Gazeta’s Russian report by Julia Latynina. Notice that the N501Y mutation in the original Chinese mice occurred after six passages of COVID-19:

SARS-CoV-2 escape in vitro from a highly neutralizing COVID-19 convalescent plasma - PubMed

Three mutations allowed SARS-CoV-2 to evade the polyclonal antibody response of a highly neutralizing COVID-19 convalescent plasma.

www.ncbi.nlm.nih.gov

’....The plasma fully neutralized the virus for 7 passages....at day 73, an E484K substitution in the RBD occurred, followed at day 80 by an insertion in the NTD N5 loop containing a new glycan sequon, which generated a variant completely resistant to plasma neutralization.’

Comparing glycan similarities with ebola:

Banana Lectin H84T

Inhibition of Ebola Virus by a Molecularly Engineered Banana Lectin - PubMed

Ebolaviruses cause an often rapidly fatal syndrome known as Ebola virus disease (EVD), with average case fatality rates of ~50%. There is no licensed vaccine or treatment for EVD, underscoring the urgent need to develop new anti-ebolavirus agents, especially in the face of an ongoing outbreak in...

www.ncbi.nlm.nih.gov

’....H84T shows activity against viruses containing high-mannose N-glycans....by mutating a single amino acid, yielding H84T BanLec.’

We point out that the Anti-COVID-19 mRNA-1273 vaccine is named after the threonine which compares to the anti-ebola banana lectin threonine.

 

[badger2]

Further comparisons to the anti-ebola banana lectin are found in the study, and the plasma sample was from an Italian patient:

SARS-CoV-2 escape in vitro from a highly neutralizing COVID-19 convalescent plasma - PubMed

Three mutations allowed SARS-CoV-2 to evade the polyclonal antibody response of a highly neutralizing COVID-19 convalescent plasma.

www.ncbi.nlm.nih.gov

’....The E484K substitution was followed by a third and final change comprising an 11-amino-acid insertion between Y248 and L249 in the NTD N5 loop (KTRNKSTSRRE). The insertion contained an N-linked glycan sequon (NKS) and this viral variant resulted in complete abrogation of neutralization activity. Initially this insertion was observed in only 49% of the virions but when the virus was kept in culture for another passage (P14) the insertion was fully acquired....Subsequently, the extensive insertion within the N5 loop appears to remodel this critical antigenic region, predicting substantial steric occlusion with antibodies targeting this epitope....introduction of a new N-glycan at position N248d would effectively eliminate neutralization by such antibodies as 4A8.
....
In the RBD, the possibility of escape is limited and the mutation E484K that we found is one of the most frequent mutations to escape monoclonal antibodies and among the most common RBD mutations described in experimental settings as well as in natural isolates posted in the GSAID database. This is likely due to residue E484 being targeted by antibodies derived from IGHV3-53 and closely related IGHV3-66 genes which are the most common germlines for antibodies directed against the RBD.

The introduction of a glycan is a well-known immunogenic strategy described in influenza, HIV-1, and other viruses, although to our knowledge this finding presents the first patient-derived escape mutant utilizing this mechanism for SARS-Cov-2.’

 

[badger2]

Following the banana lectin H84T a bit further, leads to a histidine-to-threonine connection to human macrophages and tumor recognition:

2019 Spain, Portugal, Georgia USA, The Netherlands H259T

Identification of a secondary binding site in human macrophage galactose-type lectin by microarray studies: Implications for the molecular recognition of its ligands - PubMed

The human macrophage galactose-type lectin (MGL) is a C-type lectin characterized by a unique specificity for terminal GalNAc residues present in the tumor-associated Tn antigen (αGalNAc-Ser/Thr) and its sialylated form, the sialyl-Tn antigen. However, human MGL has multiple splice variants, and...

www.ncbi.nlm.nih.gov

’....H259T was unable to recognize cancer-associated epitopes on tumor cell lines.’

 

[jbrownson0831]

They say Trump is down playing the virus because he didn't die.

As didn't 99% of the people who had it too.

 

[badger2]

The Chinese report says it’s the C-19 mutant first found in Britain:

China’s Tianjin Identifies Mutant Strain in Imported COVID-19 Case

https://www.xinhuanet.com/english/2021-01/22/c_139687889.htm

’....lived in Ghana....’

China’s Jilin Reports 19 New Confirmed COVID-19 Cases

https://www.xinhuanet.com/english/2021-01/22/c_139688801.htm

’....319 confirmed locally transmitted.’

 

[badger2]

USMB software doesn’t like the http.

www.xinhuanet.com/english/2021-01/22/c_139687889.htm

www.xinhuanet.com/english/2021-01/22/c_139688801.htm

 

[badger2]

The idea of using two different vaccines is now circulating in Russian circles.

Izvestiya, 23 Jan 2021 Ученыи отсенил возможность привится двумя вакцинами от COVID-19
Scientist Assesses Possibility Of Being Vaccinated With Two COVID-19 Vaccines

В то же время заведующии лабораториеи бионанотехнологии, микробиологии и вирусологии Новосибирского государственного университета, членкорреспондент RAN Sergei Netesov, щитает, что нельзя говорить о смешивании вакцин, пока не эавершились соответствующы.
Sergei Netesov, head of the laboratory of bionanotechnology, microbiology and virology at Novosibirsk State University and member-correspondent of the Russian Academy of Sciences, believes it impossible to talk about mixing vaccines until the relevant tests have been completed.’

 

[Rigby5]

No signs. Thus, it came from nature. The Chinese know where in nature it came from. Did the vaccine makers know too?

Yes, good point in that we already all knew that all corona viruses originated with bats.
There easily could be a deliberate aspect.

 

[Rigby5]

Science says that all epidemics are ended by herd immunity, when the initial spike uses up too many local hosts.
So then "flattening the curve" prevents epidemics from ending.
You can artificially prolong any epidemic forever, just by conserving hosts and preventing local hosts from being used up.
So all the deaths after March, are entirely the fault of Fauci and his idea for flattening the curve.

 

[badger2]

#272: No, not all coronaviruses originate with bats. What do you define as a deliberate aspect when the sequences show no manipulation that would adapt it to humans? The next thing that happened with the virus infecting Rhinolophus affinis was that its close relative evolved into COVID-19 in a different vector-reservoir. It may not have been another bat, but we think Fauci knows what happened and so do the communist Chinese.

 

[badger2]

Here, China benefits via Japanese assistance, as the media milk a pay-for C-19 origins opportunity, as can be seen by scrolling down to the unreadable ‘China Wary of WHO Investigation On Virus Origin’

読売新聞オンライン : ニュース＆お得サイト

【読売新聞】読売新聞オンラインは読売新聞のニュース・情報サイト。社会、スポーツ、政治、経済、国際などの最新ニュースや教育、医療などの読み物、映像ニュースも充実。ポケモン、発言小町、クーポンやプレゼントも。2019年2月にYOMIURI ONLINEからサイト名を変更しました。

www.yomiuri.co.jp

 

[badger2]

Another story from 14 Jan 2021 shows that two of the WHO team were stuck in Singapore:

Scientists Stuck As China Keeps Foiling WHO Investigation on Virus Origin

Scientists stuck as China keeps foiling WHO investigation on virus origin

Two scientists are stuck in Singapore as the rest of the WHO team finally makes it to Wuhan.

arstechnica.com

‘....investigators were not permitted to visit Wuhan at any point in their stay.’

 

[badger2]

True to catholic-brothers form, China Joe covers for Fauci’s silence and sloth:

22 Jan 2021 Wall Street Journal The COVID-19 Origin Investigation

Opinion | The Covid-19 Origin Investigation

Beijing spreads conspiracies while impeding WHO experts.

www.wsj.com

’....Biden stopped America’s withdrawal from WHO on his first day in office.’

 

[badger2]

Thus like yomiuri.co.jp, WSJ attempts to profit from knowledge the communists already possess about the virus.

 

[Dalia]

Mutant variant of coronavirus 'is probably already in the US and could even have STARTED in America'

Hello, here in France the medias are talking about 4 variants and the last one L452R variant of COVID-19 is in California .

COVID-19 Variant First Found in Other Countries and States Now Seen More Frequently in California - Novel Coronavirus (COVID-19) - County of Santa Clara

 

[badger2]

Yes, the dramatizations and timing by French media while WHO visits China for the second time, links to this mutation, L452R(leucine to arginine), and there is only one report on this mutation at the National Library of Medicine, USA:

Sep 2020 L452R, Authors of This Study: Canada / China / Who Collaborating Center (China)

The Impact of Mutations in SARS-CoV-2 Spike on Viral Infectivity and Antigenicity - PubMed

The spike protein of SARS-CoV-2 has been undergoing mutations and is highly glycosylated. It is critically important to investigate the biological significance of these mutations. Here, we investigated 80 variants and 26 glycosylation site modifications for the infectivity and reactivity to a...

www.ncbi.nlm.nih.gov