Can Anybody Conduct A Fair Study For HCL?

JimofPennsylvan

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Jun 6, 2007
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Throughout this crisis the experts have been hammering on the wisdom of "follow the science"; but the experts that control approval of the drug hydroxychloroquine for the disease Covid 19 haven't been following this advice! These leaders have been loudly proclaiming that they have to wait for the studies to be completed to determine whether this drug is efficacious with respect to Covid 19. But the design of many of the studies are devoid of intelligence they completely ignore the science on how the drug works on how it affects the body; the American people expect and deserve that America's leadership on this issue stop acting like a bunch of simpletons!

I am not a doctor or a scientist but I know how to read the literature on hydroxychloroquine (HCL) and that is all one needs to do to know what is the right thing that should be occurring here. HCL has been around for decades and so the medical profession is fairly confident on how it works what it does in the human body. It does three major things. One, it interferes with a viruses construction of protein structures, receptors, that are embedded in the outer wall of the virus these structures enable the virus to identify and latch on to target cells, that is a persons good cells. Secondly, HCL slows down and interferes with the the process where good cells take in the virus; good cells encapsulate foreign matter and then process it into the depth of the cell, it is called endocytosis. The way that HCL does this it is an alkaline chemical and so when it enters the body it makes cells more alkaline, it raises the ph in the cell; if a cell's ph is lowered it becomes more acidic and the more acidic the environment in a cell the better the the environment for molecular activity, the connecting and breaking down of molecules. Thirdly, what HCL does is it obstructs the activation of dendritic immune cells. Dendritic cells are known as sentinel cells because of the role they play in fighting foreign substances in the body their role is that when the identify a foreign invader they go back to the lymph nodes and alert the bodies T immune cell and B immune cells residing in the lymph nodes which then come to the location of the foreign invader and fight that invader. To put it another way what HCL does is it blocks the activation of Dendritic cells which blocks the activation of a large portion of a persons immune system that is why HCL is a good drug to treat some autoimmune diseases because it blocks activation or causes suppression of a significant portion of a person's immune system.

This third aspect of how HCL works seems to be ignored by scientist and doctors designing the current HCL studies because they are putting patients in these studies that don't have sound immune systems they are admitting patients with weakened immune systems. For a human being to beat the Covid 19 disease that human being's immune system will have to beat the viral disease if you know such a person's immune system is significantly weaker than a fully healthy immune system why for heaven sake would one disable a significant portion of that person's immune system which the health officials are doing by putting such a patient on HCL.

In the last two days the media has been waving around an observational study on HCL by a large medical Center in New York City where the medical records of essentially all the Covid 19 patients admitted from March 7 thru April 8 of this year numbering 1376 patients were studied. Fifty-nine percent (811) were put on a regimen of HCL and the study found that the risk of death an/or intubation was not affected by the use of HCL; many in the media are holding this study out as proof that HCL is a failure as a therapeutic for Covid 19. Of the HCL population 367 were of the age 60 to 79 and 147 were over 80 maybe those close to 60 don't deserve to be classified as having a weakened immune system but those over seventy common sense would indicate ordinarily deserve such classification and there is a lot of such patients in the study. Of the HCL population past diagnosis results included the following 146 w/chronic lung disease, 301w/diabetes 109 w/cancer, 133 w/chronic lung disease and 40 on immune suppressive medications; again a lot of patients with weakened immune systems not good candidates for HCL pursuant to the science on the drug not to mention there exist reliable medical literature that concludes people with diabetes are not good candidates for HCL that the disease of diabetes impairs the processing of the drug by the human body. Also, this study examined patients that received 1.2 grams of HCL on their first day of receiving a treatment, one pharmaceutical company that makes HCL generally recommends a 400 mg dosage per day; this is a toxic drug there is authority that says 1.5-2.0 grams in a day of the sister drug chloroquine is clearly a toxic amount, the toxic effect can cause a fatal effect on the lungs and with the heart from the high level of HCL given patients in this study it isn't a fair study. The American people need some good and courageous doctors to step-up here and call for taking politics out of the evaluation of this drug and call for fair studies of the drug based on the known science of the pharmaceutical!
 
The state of South Dakota is currently conducting a statewide clinical trial to answer the question to, hopefully, everyone’s satisfaction. I agree that the drug has been around a long time so its side effects are well known. People who have risk factors associated with those known side effects should probably avoid it but for others, it should be up to them to try it if they want to do so, IMHO.
 
Throughout this crisis the experts have been hammering on the wisdom of "follow the science"; but the experts that control approval of the drug hydroxychloroquine for the disease Covid 19 haven't been following this advice! These leaders have been loudly proclaiming that they have to wait for the studies to be completed to determine whether this drug is efficacious with respect to Covid 19. But the design of many of the studies are devoid of intelligence they completely ignore the science on how the drug works on how it affects the body; the American people expect and deserve that America's leadership on this issue stop acting like a bunch of simpletons!

I am not a doctor or a scientist but I know how to read the literature on hydroxychloroquine (HCL) and that is all one needs to do to know what is the right thing that should be occurring here. HCL has been around for decades and so the medical profession is fairly confident on how it works what it does in the human body. It does three major things. One, it interferes with a viruses construction of protein structures, receptors, that are embedded in the outer wall of the virus these structures enable the virus to identify and latch on to target cells, that is a persons good cells. Secondly, HCL slows down and interferes with the the process where good cells take in the virus; good cells encapsulate foreign matter and then process it into the depth of the cell, it is called endocytosis. The way that HCL does this it is an alkaline chemical and so when it enters the body it makes cells more alkaline, it raises the ph in the cell; if a cell's ph is lowered it becomes more acidic and the more acidic the environment in a cell the better the the environment for molecular activity, the connecting and breaking down of molecules. Thirdly, what HCL does is it obstructs the activation of dendritic immune cells. Dendritic cells are known as sentinel cells because of the role they play in fighting foreign substances in the body their role is that when the identify a foreign invader they go back to the lymph nodes and alert the bodies T immune cell and B immune cells residing in the lymph nodes which then come to the location of the foreign invader and fight that invader. To put it another way what HCL does is it blocks the activation of Dendritic cells which blocks the activation of a large portion of a persons immune system that is why HCL is a good drug to treat some autoimmune diseases because it blocks activation or causes suppression of a significant portion of a person's immune system.

This third aspect of how HCL works seems to be ignored by scientist and doctors designing the current HCL studies because they are putting patients in these studies that don't have sound immune systems they are admitting patients with weakened immune systems. For a human being to beat the Covid 19 disease that human being's immune system will have to beat the viral disease if you know such a person's immune system is significantly weaker than a fully healthy immune system why for heaven sake would one disable a significant portion of that person's immune system which the health officials are doing by putting such a patient on HCL.

In the last two days the media has been waving around an observational study on HCL by a large medical Center in New York City where the medical records of essentially all the Covid 19 patients admitted from March 7 thru April 8 of this year numbering 1376 patients were studied. Fifty-nine percent (811) were put on a regimen of HCL and the study found that the risk of death an/or intubation was not affected by the use of HCL; many in the media are holding this study out as proof that HCL is a failure as a therapeutic for Covid 19. Of the HCL population 367 were of the age 60 to 79 and 147 were over 80 maybe those close to 60 don't deserve to be classified as having a weakened immune system but those over seventy common sense would indicate ordinarily deserve such classification and there is a lot of such patients in the study. Of the HCL population past diagnosis results included the following 146 w/chronic lung disease, 301w/diabetes 109 w/cancer, 133 w/chronic lung disease and 40 on immune suppressive medications; again a lot of patients with weakened immune systems not good candidates for HCL pursuant to the science on the drug not to mention there exist reliable medical literature that concludes people with diabetes are not good candidates for HCL that the disease of diabetes impairs the processing of the drug by the human body. Also, this study examined patients that received 1.2 grams of HCL on their first day of receiving a treatment, one pharmaceutical company that makes HCL generally recommends a 400 mg dosage per day; this is a toxic drug there is authority that says 1.5-2.0 grams in a day of the sister drug chloroquine is clearly a toxic amount, the toxic effect can cause a fatal effect on the lungs and with the heart from the high level of HCL given patients in this study it isn't a fair study. The American people need some good and courageous doctors to step-up here and call for taking politics out of the evaluation of this drug and call for fair studies of the drug based on the known science of the pharmaceutical!
No one fully knows how HCL will react in the human body with the new manmade bioweapon present.

So seriously do not believe the studies that are all screened and altered so that we hear what we need to hear which will never be the truth.

Or do you believe the government?
 

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