'Universal' cancer vaccine developed

Discussion in 'Science and Technology' started by Matthew, Apr 8, 2012.

  1. Matthew
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    Matthew Blue dog all the way!

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    'Universal' cancer vaccine developed

    A vaccine that can train cancer patients' own bodies to seek out and destroy tumour cells has been developed by scientists.


    The therapy, which targets a molecule found in 90 per cent of all cancers, could provide a universal injection that allows patients' immune systems to fight off common cancers including breast and prostate cancer.


    Preliminary results from early clinical trials have shown the vaccine can trigger an immune response in patients and reduce levels of disease.


    The scientists behind the vaccine now hope to conduct larger trials in patients to prove it can be effective against a range of different cancers.


    They believe it could be used to combat small tumours if they are detected early enough or to help prevent the return and spread of disease in patients who have undergone other forms of treatment such as surgery.


    Cancer cells usually evade patient's immune systems because they are not recognised as being a threat. While the immune system usually attacks foreign cells such as bacteria, tumours are formed of the patient's own cells that have malfunctioned.



    Scientists have, however, found that a molecule called MUC1, which is found in high amounts on the surface of cancer cells, can be used to help the immune system detect tumours.

    The new vaccine, developed by drug company Vaxil Biotheraputics along with researchers at Tel Aviv University, uses a small section of the molecule to prime the immune system so that it can identify and destroy cancer cells.

    A statement from Vaxil Biotheraputics said: "ImMucin generated a robust and specific immune response in all patients which was observed after only 2-4 doses of the vaccine out of a maximum of 12 doses.

    "In some of the patients, preliminary signs of clinical efficacy were observed."

    The results are still to be formally published but if further trials prove to be successful the vaccine could be available within six years.

    As a therapeutic vaccine it is designed to be given to patients who are already suffering from cancer to help their bodies fight off the disease rather than to prevent disease in the first place.

    Cancer cells contain high levels of MUC1 as it is thought to be involved helping tumours grow. Healthy human cells also contain MUC1, but have levels that are too low to trigger the immune system after vaccination.

    When a vaccinated patient's immune system encounters cancer cells, however, the far larger concentration of MUC1 causes it to attack and kill the tumour.

    As MUC1 is found in 90 per cent of all cancers, the researchers believe it could be used to combat the growth and spread of a wide range of cancers.

    In a safety trial at the Hadassah Medical Centre in Jerusalem, ten patients suffering from multiple myeloma, a form of blood cancer, have now received the vaccine.

    Seven of the patients have now finished the treatment and Vaxil reported that all of them had greater immunity against cancer cells compared to before they were given the vaccine.

    Vaxil added that three patients are now free of detectable cancer following the treatment.

    The findings support research published in the journal Vaccine, which showed the treatment induced "potent" immunity in mice and increased their survival from cancer.

    Cancer charities have given the vaccine a cautious welcome, but warned further testing was needed before it could be approved for widespread use.

    There are currently a number of other therapeutic vaccines against cancer being tested, but they have met with limited success.

    Dr Kat Arney, science information manager at Cancer Research UK, said: "There are several groups around the world investigating treatments that target MUC1, as it's a very interesting target involved in several types of cancer.

    "These are very early results that are yet to be fully published, so there's a lot more work to be done to prove that this particular vaccine is safe and effective in cancer patients."
    'Universal' cancer vaccine developed - Telegraph
     
  2. sparky
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    sparky VIP Member

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    Matt,
    you do realize the repetitive miracle cure(s) foisted upon us gets to be a cry wolf deal raising false hopes among the hopeless....~S~
     
  3. Douger
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    Douger BANNED

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    Tests shall continue till 2027 before human trials take place.
    BUY OUR STOCK !!!
     
    Last edited: Apr 8, 2012
  4. Sarah G
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    Sarah G When Nothing Goes Right, Go Left Supporting Member

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    Cancer drugs are very profitable for big pharma. There will never be a complete cure.
     
  5. whitehall
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    whitehall Gold Member

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    You are wrong on a couple of points matt. First of all a vaccine is something that produces immunity to a disease. This stuff isn't even alleged to "cure" cancer. It just stimulates an immune response.
     
  6. mudwhistle
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    mudwhistle Diamond Member

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    You EVIL Flat-earther rightwinger.

    *just kidding*
     
  7. dilloduck
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    dilloduck Diamond Member

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    You anti-semites !
     
  8. mudwhistle
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    mudwhistle Diamond Member

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    If that's so why did Obama work out a deal with them back in 09'.

    Seems Obama sold us down the river just so he could have a major legislative accomplishment to hang his hat on.

    But carry on.......

    Hope nobody accuses you of being a heartless rightwinger.

    LINKS

    Internal Memo Confirms Big Giveaways In White House Deal With Big Pharma
    Obama Quietly Cozies Up to Health-Care Industry - The Daily Beast
    Obama's $80 Billion Deal with Pharma Is a Very Bad Deal for Us | Personal Health | AlterNet
     
    Last edited: Apr 8, 2012
  9. uscitizen
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    uscitizen Senior Member

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    More American exceptionalism and innovation, the reason why Big pharma is allowed to charge more for drugs in the USA than for the same drug abroad.
     

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