Snake Meat......source of chinese virus

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The evidence suggests that COVID-19-vaccinated Chinese miners proposed for New Guinea kuru country was more than a coincidence, and here we link the all-important lysosome in chloroquine-hydroxychloroquine pharmacodynamics to prion disease:

Lysosomal Quality Control / Prions
'....the lysosomal quality control machinery emerges as one of the primary targets exploited by the disease-causing isoforms.'
 
In long-term experimental chloroquine myopathy, prion proteins accumulate:

Kyushu / Experimental Chloroquine Myopathy
'....PrP accumulation was immunohistochemically demonstrated in autophagic vacuoles in degenerated muscle fibers.'
 
Nervous necrosis virus was mentioned in post #979. Pubmed search, 'nervous necrosis virus bream,' because white bream virus is related to coronaviruses, mentioned in The Nidoviruses: Coronaviruses and Arteriviruses. The search yields entries for Gilthead Sea Bream, Sparus aurata. This will link to polyoma viruses in Canadian bats as well as Myotis californicus. Note the asymptomatic aspect of this infection:

White Bream Nidovirus

Nervous Necrosis Virus / Sparus aurata

Sparus aurata / Nodavirus / Asymptomatic

SaPYV1

Polyoma Coronavirus / Canadian Bats / Myotis californicus

We mentioned interferon-stimulated gene 15 in posts # 630 and # 733:

Sparus aurata Interferon-Stimulated Gene
 
The link in post #631 is incorrectly transcribed, though is the link to ebola vaccine (vesicular stomatitis virus) as well as heron hepatitis virus:

Nodamura Virus
 
We learn from post #630 that nsp3 (non-structural protein 3) is the largest in the coronavirus genome. We searched, 'nsp3 covid-19' and retrieved an eye-catching report from Brazilian dermatology:

Jul 2020 Brazil COVID-19 / Dermatology
'....polymorphous cutaneous lesions....blue toe....'

COVID-19 and blue toes was mentioned in the USMB thread titled, "Blue Toes or Blue Fingertips Could Mean You Have the Virus!" Thus murine hepatitis coronavirus links ISG-15, NF-kappaB and blue toe in COVID-19.
 
In this Icelandic report, antibodies against C-19 are produced in waves:

2 Sept 2020 Iceland COVID-19 Study
'....a second wave of antibodies forms and grows steadily during the first two months after infection.'
 
Snake meat sounds like an interesting dinner idea :smoke:

51Wm7zpPcqL._SY300_.jpg
 
Bret Weinstein's video, "Why COVID-19 May Have Leaked From A Lab," mentions furin site and two arginines, the arginines apparently not occurring in nature, at timepoint 5:40. This is the argument for a lab-designed virus, though Weinstein's credibility becomes questionable when we find a coronavirus expert, Foley, linked to La Jolla, California, also the location of a double-arginine report:

Bret Weinstein: Why COVID-19 May Have Leaked From A Lab

'....one of the enhancements....furin site....arginine....'

(1994) Scripps Research Institute, La Jolla, California / RR Motif Arginines
'....RR-tagged transferrin receptor partially localized to the intermediate compartment....'
 
The transferrin link adds some genes to the list:

Jul 2020 Is Transferrin A Missing Link?
 
Here we link Robin Williams and lewy body dementia to chloroquine. Because potential intermediate COVID-19 hosts and models include the porpoise and hamster, respectively (previous posts) and this intermediate C-19 host list includes Bovidae, a video of interest is Robin Williams, "Dolphin Evolution."

youtube.com/watch?v=Bqj2JnwodqM

4 Sept 2020 Tom Seaver-Robin Williams Lewy Body Dementia

Greece, Hungary, Germany, California / Chloroquine / Lewy Bodies
'....The autophagy-lysosome pathway (ALP) regulates the intracellular homeostasis of the cytosolic protein SNCA/alpha synuclein, which is tightly linked to age-related neurodegenerative synucleinopathies, including Parkinson;s disease (PD) and dementia with lewy bodies (DLB)....endosomal sorting complex required for transport (ESCRT) complex....Treatment with 50 microM of the ALP inhibitor chloroquine (CQ) also upregulated total extracellular SNCA (synuclein alpha) levels by 2.5-fold....We found that 20 nM Baf (bafilomycin) led to approximately 20% fewer cells while no cell loss was observed with CQ. In each of the conditions assessed, more than 95% of cells detected were trypan blue negative, and therefore intact....In contrast, the ALP inducer, rapamycin, had no influence on extracellular SNCA levels....several ALP-related components were identified in extracellular vesicles....LAMP2....in H4 EVs: Rab11.'
 
One of these URLs should function in the spacebar:





With the furin cleavage site of previous posts, there will be ebola, Zika, and fruit-bat parainfluenza connections. With the Rab11 of post #991, there will be a Zika connection to Rab5 in the Warburg Micro and Martsolf Syndromes, which mostly concerns Rab3GAP1 and RAB3GAP2. In these latter syndromes, of interest are the GTP-linked geranylgeranyl moieties, which have a relation to SARS-CoV-2, in this study:

SARS-CoV-2
 
We make the geranylgeranyl connection in coronaviruses because one symptom in Micro syndrome is, like Zika infection, microcephaly.

'....ZA (zoledronic acid) could plausibly attack the endosomal trafficking central to SARS-CoV-2 infection. ZA inhibits the prenylation of small guanine-nucleotide-binding regulatory proteins (G-proteins) such as Rab family members through inhibition of geranylgeranyl transferases. Rab GTPase family members are involved in endosomal trafficking, including compartmentalization into early, recycling, late and lysosomal routes.'
 
Further on the transferrin trajectory, there is....

Is Transferrin A Missing Link?

'....ADAMTS13, F11, HGFAC, KLKB1 (procoagulants), two anticoagulants C1QTNF1, SERPINA5....expression of procoagulant transferrin (not associated with the Gene Ontology term, "blood coagulation") was higher in males, increased with age, and was upregulated upon SARS-CoV-2 infection.

The Italians were looking for scrapie in porpoise brains, though there are no published reports of this having occurred.

Transferrin / Prion / Scrapie
....Emerging evidence implicates an imbalance of brain iron homeostasis as a significant cause of prion disease-associated neurotoxicity....The underlying cause is change in the characteristics of ferritin, an iron-storage protein that becomes aggregated, detergent insoluble, and partitions with denatured ferritin using conventional methods of ferritin purification. A similar phenotype of iron deficiency is noted in lumbar spinal cord (SC) tissue of scrapie-infected hamsters, a site unlikely to be affected by massive neuronal death and non-specific iron deposition. As a result, the iron uptake protein, transferrin (tf) is upregulated in scrapie-infected SC tissue, and increases with disease progression.'
 
In post #991 was posted the chloroquine/lewy body study. To make the snake connection, we first excerpt from that study:

....Several ALP-related protein components were identified in extracellular vesicles: LAMP2 (lysosomal associated membrane protein 2) and HSPA/HSP70 (heat-shock protein 70) could specifically be correlated with Alzheimer's disease progression....in H4 extracellular vesicles: Rab11....sumoylation, previously shown to stimulate the ALP-mediated degradation of SNCA, directs its sorting to vesicles....using PC 12 cells, the process of exophagy was proposed to underlie increase of extracellular SNCA in conditional media fractions positive for the late endosome/amphisome markers ANXA5 and Rab27a.'

"Late" Macroendosomes and Acidic Endosomes in Vertebrate Motor Nerve Terminals
'....Garter snake, Thamnophis sirtalis, were housed as previously described....were rapidly sacrificed by decapitation....AEs (acidic endosomes) share biochemical and immunohistochemical markers (e.g., lysosome-associated membrane protein 1 [LAMP-1])....Based on our data, we propose that MEs (macroendosomes) serve as sorting endosomes.'
 
Rattlesnakes (post #988) also link to lysosomes:

'....Overall, our data suggests that lysosomes are the primary targets for crotamine toxicity.'

Crotoxin / MCF-7 Breast Cancer
htps://www.ncbi.nlm.nih.gov/pubmed/17376294
 
In the chloroquine-lewy body study linking LAMP2, Table 1. Clicking on that link will include another asymptomatic entry as well as another arginine entry for the COVID-19 files:

DAND Arg-321 / Asymptomatic HyperCKemia / TLR7/9

Using a TLR7 search, there is thus a connection to the COVID-19 hyperimmune response:

COVID-19 / TLR7
'....An immunoinformatic approach showed that the SARS-CoV-2 genome has more ssRNA fragments that could be recognized by TLR7/8 than the SARS-CoV genome. These findings suggest innate immune hyperactivation by SARS-CoV-2....possibly able to provoke a robust inflammatory response via TLR7/8 and cause acute lung injury.'
 
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