Snake Meat......source of chinese virus

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Next, we link geraniol to ACE2 downregulation, because it is the target of COVID-19:

Geranium and Lemon Essential Oils and Their Active Compounds Downregulate Angiotensin-Converting Enzyme 2 (ACE2), a SARS-CoV-2 Spike Receptor-Binding Domain, in Epithelial Cells - PubMed

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), also known as coronavirus disease-2019 (COVID-19), is a pandemic disease that has been declared as modern history's gravest health emergency worldwide. Until now, no precise treatment modality has been developed. The...

www.ncbi.nlm.nih.gov

 

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Teacher shortages and changing curiculums are in the news:

28 Aug 2020

Teacher shortages are a big problem in the U.S. The coronavirus pandemic could make it worse.

There was a national teacher shortage before COVID-19. The pandemic complicates the problem.

yahoo.com

'....There simply are not enough human resources available to cover face-to-face learning needs of our students safely and with health as a priority.'

 

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Multiple clusters occurring at NC State, as students leave dorms:

27 Aug 2020

NC State University's 'Unrelenting' Spread Of COVID-19 Forces Students To Leave Dorms

Students moved in on Aug. 10, switched to online courses Monday and now most have to leave campus entirely.

yahoo.com

'....twenty-four coronavirus clusters....'

 

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Like Russia's vaccine, AstraZeneca's is also adenovirus-based:

24 Aug 2020 UK's AstraZeneca Vaccine Gets Russian Nod

AstraZeneca Receives Russian Nod For Covid-19 Vaccine Trial- Report

UK biopharma AstraZeneca (AZN) has now received regulatory approval to hold part of a late-stage trial for its potential COVID-19 vaccine in Russia, according to a report from Reuters.The Phase III trial of the AZD1222 vaccine will involve 150 people and will take place in four medical sites in...

finance.yahoo.com

 

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The transition to neurotrophic symptoms may reflect COVID-19's mutational changes in what may be Russia's first case of reinfection:

26 Aug 2020 Governor of Tuva Reinfected with Coronavirus

Siberian Governor ‘Reinfected’ With Coronavirus - The Moscow Times

The head of a remote Siberian region has contracted the coronavirus a second time in what may be Russia’s first documented case of reinfection. Sholban Kara-Ool, the governor of the republic of Tyva on the Mongolian border, was admitted to the hospital again this week three months after his...

www.themoscowtimes.com

 

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COVID-19-vaccinated Chinese miners in New Guinea (previous posts) may not be coincidental:

May 2020 India, Thailand, South Korea / Parkinson's / COVID-19 / Neurotrophic Viruses

COVID-19: An Early Review of Its Global Impact and Considerations for Parkinson's Disease Patient Care - PubMed

While many infectious disorders are unknown to most neurologists, COVID-19 is very different. It has impacted neurologists and other health care workers, not only in our professional lives but also through the fear and panic within our own families, colleagues, patients and their families, and...

www.ncbi.nlm.nih.gov

'....Though the possibilities presented are speculative, they are theory-based, and supported by prior evidence from other neurotrophic viruses closely related to SARS-CoV-2. Neurologists should be on high alert and vigilant for potential acute and chronic complications when encountering PD patients who are suspected of having COVID-19.'

 

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As of today, ProMed-mail has gone esoteric, and now requires a subscription.

 

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Restaurant sales are down 91% in San Francisco, as the state prepares for flu season:

26 Aug 2020 San Francisco / Prep for "Twindemic"

CA preparing for 'twindemic' as flu season approaches, now guarantees COVID-19 results in 24-48 hours

Newsom said the state will produce an additional 150,000 COVID-19 tests per day, with a guaranteed turnaround time of 24 to 48 hours.

www.abc7news.com

 

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One of these models was originally used to detect a woman's ovulation state (Avian Flu Talk / COVID-19 Discussion Forum)

COVID-19-Flu Predictions Models

Can a Wearable Detect Covid-19 Before Symptoms Appear?

Stanford researchers hope to find the answer, which could impact health care beyond the current pandemic.

www.wired.com

Dutch UMC Utrecht wristband detects exposure to COVID-19 before you even notice

An electronic wristband designed to signal when ovulation takes place is now being used to detect a potential contamination with COVID-19.

innovationorigins.com

 

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Promedmail is apparently back online, no subscription required.

 

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An academically dense report, we'll initially excerpt for autopsy, because it resonates with Alzheimer's classic first autopsy and with kuru, recalling that Gajdusek did not require a stethoscope to hear kuru-infected Yakurimba's heart rub, 3 to 4 feet out from the body:

Jun 2020 Pakistan, Massachusetts / Neuroinvasive COVID-19

Potential neuroinvasive pathways of SARS-CoV-2: Deciphering the spectrum of neurological deficit seen in coronavirus disease-2019 (COVID-19) - PubMed

Coronavirus disease-2019 (COVID-19) was declared a global pandemic on 11 March 2020. Scientists and clinicians must acknowledge that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has the potential to attack the human body in multiple ways simultaneously and exploit any weaknesses...

www.ncbi.nlm.nih.gov

'....The majority of initial published and available reports from China involving autopsy, predominantly focused on procedure safety with scarce actual autopsy and pathology reports. Remarkably, only one full autopsy report was identified and able to be accessed in the full text during the early days of the COVID-19 outbreak in China. Even after the spread of COVID-19 in U.S. and Europe, with hundreds of deaths daily, autopsy examinations were not routinely performed and crucial data on organ involvement, and the CNS in particular, remained uninvestigated.

Notably, China has had markedly more time than the rest of the world to perform clinical investigations and autopsy examinations. Despite this advantage, there was an initial paucity of published autopsy and pathology reports on the CNS. Physicians and scientists from China have been vocal about their recommendations and need for more data. Dr. Bin Cong, physician and dean of Hubei Medical University School of Forensic Medicine, published a paper in Feb 2020 requesting to strengthen the use of autopsy to better comprehend COVID-19. Dr. Hujun Wang, physician and chief expert in forensic medicine at Southern Medical University, also recognized the need of pathologic data on patients with COVID-19 to better understand the infection.'

Interestingly, Wang is speaking up during the same month that COVID-19 mutated, and so the headache symptom coupled to reinfection from Tuva (previous post) may have genetic implications that link to neuroinvasiveness. Further, Trump recently calls for convalescent plasma, and this links to the precise mutation, D614G, an aspartic acid to glycine mutation. We immediately intuit some of its primitivity: the glycine of the Miller-Urey volcanic spark experiment of 1959:

COVID-19 Mutation D614G / Convalescent Plasma

The D614G mutation in the SARS-CoV-2 spike protein reduces S1 shedding and increases infectivity - PubMed

SARS coronavirus 2 (SARS-CoV-2) isolates encoding a D614G mutation in the viral spike (S) protein predominate over time in locales where it is found, implying that this change enhances viral transmission. We therefore compared the functional properties of the S proteins with aspartic acid (S...

www.ncbi.nlm.nih.gov

 

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In passing it should be mentioned that the isoelectric point of aspartic acid is 2.98, whereas that of glycine is 6.06. In the volcanic spark experiments of Miller-Urey, glycine and alanine were predominant. We see some resonance in kuru plaques, and note the triple glycines and the alanine-to-valine mutation, the latter being also found in Alzheimer's (both A--->V and V---->A):

(1991) Japanese CJD

[Recent advances in the research of Creutzfeldt-Jakob disease (CJD) and Gerstmann-Strüssler syndrome (GSS)] - PubMed

The abnormal isoform of prion protein (PrP) was detected by Western blotting and immunohistochemistry in all brains of 53 CJD and 20 GSS patients. Formic acid pretreatment on formalin fixed, paraffin-embedded thin sections enhanced immunostaining of PrP in both congophilic and non-congophilic...

www.ncbi.nlm.nih.gov

'....7 sporadic CJD patients with kuru plaques....'

 

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Returning to the report of post #971, "Potential Neuroinvasive Pathways of SARS-CoV-2" we first link tetraparesis mentioned there to COVID-19, followed by a tetraparesis link to chloroquine, dexamethasone and prednisone as well as vitamins, recalling that glucocorticoids have been contraindicated in COVID-19 therapy.

Potential Neuroinvasive Pathways, continued
'....Guillain-Barre syndrome (GBS) case series from Italy reported five cases, 4 of which developed flaccid teraparesis or tetraplegia, 3 required mechanical ventilation. The CSF of all 5 tested negative for SARS-CoV-2.'

Feb 1970 Tetraparesis / Chloroquine

Remarkable recovery of a steroid-responsive recurrent polyneuropathy - PubMed

Remarkable recovery of a steroid-responsive recurrent polyneuropathy

ncbi.nlm.nih.gov

'....Oral prednisone therapy....does of 15 mg t.i.d. potassium chloride syrup (60 m-equiv daily) and antacids were also given in conjunction with the glucocorticoid....other medications included chloroquine 125 mg b.i.d. from 25 Jan 1968 through until 27 Aug 1968, during which time the patient received a total dosage of 55 g. Supplemental vitamins....pyridoxine hydrochloride 25 mg daily.
....
The response to glucocorticoid therapy, although ultimately rewarding, was preceded by a latency period of 3.5 months, during which interval there was only very minimal clinical evidence suggesting recovery.'
(to be continued)

 

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'Remarkeble Recovery of a Steroid-Responsive Recurrent Polyneuropathy (post #973) continues:

'The patient's first exacerbation had evolved abruptly over 48 hours after an indolent course of several months; treatment with dexamethasone in low doses (total dose of 20 mg over 30 days) was rather promptly beneficial. The second exacerbation had evolved more slowly; treatment with dexamethasone in much higher doses Total dose of 165 mg over six weeks was followed by a latency period of three to four weeks before clinical remission became apparent. With the third exacerbation, the patient remained quadriplegic for over 13 months before prednisone treatment was begun.

Although there was minimal evidence of benefit documented by weekly improvements in vital capacity measurements and subtle changes in detailed manual muscle testing, a latency period of 3.5 months elapsed before functional recovery could be clearly demonstrated.
....
Chloroquine has long been known to have certain 'anti-inflammatory' properties (Sams, 1967). In vitro, this drug is as effective as the glucocorticoids in inhibiting lymphocyte transformation induced by phytohaemagglutinin (Hirschhorn & Hirschhorn, 1965). It is perhaps by preventing small lymphocytes from undergoing blastic transformation in vivo that glucocorticoids, and possibly chloroquine, interrupt the proposed immunological sequence in idiopathic recurrence neuropathy, and produce a clinical remission.

It seems reasonable to suggest that 1.) the chronic neuropathy in the presented case is perpetuated by a lymphocyte-mediated process of delayed hypersensitivity and 2.) glucocorticoids, and possibly chloroquine, act by blocking lymphocyte reactivity to effect a remission.'

 

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Comparable with the lymphocyte-mediated delayed hypersensitivity of post #974 is post #851 of 7 Aug 2020, wherein we linked COVID-19/Kawasaki to delayed reaction in Italian children, which pointed to the porphyria cutanea tarda of post #845.

 

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One from Yale who has written extensively on hydroxychloroquine:

Dr. Fauci's Hydroxychloroquine Denial

https://www.realclearpolitics.com/articles/2020/08/31/dr_faucis_hydroxychloroquine_denial-144095.html

 

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Risch (Yale) is on track by advocating the addition of zinc. Importantly, he also mentions Zelenko:

The Key to Defeating COVID-19 Already Exists. We Need to Start Using It

The key to defeating COVID-19 already exists. We need to start using it | Opinion

Contrary to what you hear, there is clear-cut medical evidence for the efficacy of hydroxychloroquine.

www.newsweek.com

 

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A zinc trajectory with more connections, this one being a cardiac link to a zinc homeobox gene (ZFHX3) and micro-RNAs(mirnas, previously mentioned in the thread):

Arrhythmia / Zinc / Atrial Remodeling / Mirna-133

MicroRNA-133 suppresses ZFHX3-dependent atrial remodelling and arrhythmia - PubMed

ZFHX3-KD promotes distinct miRNA expressional changes in atrial myocytes. MiR-133a/b mimics may reverse signalling of ZFHX3 KD-mediated cardiac remodelling and atrial arrhythmia.

www.ncbi.nlm.nih.gov

As quickly as possible, one may wish to link PTEN to COVID-19, because PTEN links to ATBF1, the latter being a ZFHX3 connection:

A Pubmed search 'PTEN SARS-CoV-2' yields 3 references, and this one mentions the crucial COVID-19 duo, ACE2-TMPRSS2:

PTEN / SARS-CoV-2 / Furin / DPP4 Axis / ACE2 / TMPRSS2

Age-dependent assessment of genes involved in cellular senescence, telomere and mitochondrial pathways in human lung tissue of smokers, COPD and IPF: Associations with SARS-CoV-2 COVID-19 ACE2-TMPRSS2-Furin-DPP4 axis - PubMed

Aging is one of the key contributing factors for chronic obstructive pulmonary diseases (COPD) and other chronic inflammatory lung diseases. Cigarette smoke is a major etiological risk factor that has been shown to alter cellular processes involving mitochondrial function, cellular senescence...

www.ncbi.nlm.nih.gov

Around 5 Feb 2020, we mentioned DPP4 in posts # 268, 269, 282, 283, and 316.

 

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In Hydroxychloroquine: A Morality Tale, Doidge does not mention zinc, but mentions a Wuhan Chinese 'intuition' about lupus and the use of hydroxychloroquine, which we will refute as a dramatization. We do so while linking back to the neurotropic trajectory of COVID-19, as well as the Baruch S. Blumberg Foundation's connection to Wuhan via GILT. This is also a liver virus trajectory, due to nodavirus in herons, which also suffer from HHV (heron hepatitis virus):

Ap 2020 Nodavirus / Chloroquine / South China Agricultural University

Autophagy Participates in Lysosomal Vacuolation-Mediated Cell Death in RGNNV-Infected Cells - PubMed

Nervous necrosis virus (NNV) is the etiological agent of viral nervous necrosis (VNN), also known as viral encephalopathy and retinopathy (VER), which results in heavy economic losses to the aquaculture industry worldwide. Dramatic cytoplasmic vacuoles were observed during NNV infection both...

www.ncbi.nlm.nih.gov

'....viral nervous necrosis (VNN), otherwise termed viral encephalopathy and retinopathy (VER), caused by nervous necrosis virus (NNV) (genus Betanodavirus, family Nodaviridae), is a highly infective neuropathological disease that can be detected in more than 177 marine species worldwide.'

We mentioned South China Agricultural University around 15 Feb 2020 in posts # 419, 582 and 583. A list of the 177 nodavirus-infected species should be interesting.

 

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Next we link 'dramatic cytoplasmic vacuoles' of nodavirus (post #979) to kuru:

Kuru Vacuolation

Neuropathology and the scrapie-kuru connection - PubMed

When their kinship was surmised 35 years ago, scrapie and kuru were linked mainly by their neuropathologic similarity. Most notable were neuronal degeneration and intense astrocytosis with little, if any, inflammation. Especially eye-catching in kuru were the vacuolated neurons--the histologic...

www.ncbi.nlm.nih.gov

'....especially eye-catching in kuru were the vacuolated neurons -- the histologic hall-mark of scrapie that drew me to the human disease from the start.'