Sickle cell anemia is not common but still affecting lots of peoples in the United States and rest of the world. The red blood cells in normal human body making hemoglobin are round and smooth and gliding through small blood vessels. Sickle anemia patient cells are not round, it is like the shape of sickle (from which we use to cut wheat). These cells which looks crescent like get stuck in blood vessels and due to this the blood flow blocks which resulting severe pain in different body parts and sometimes damages the organs too.