First Gene Therapy Successful Against Aging-Associated Decline: Mouse Lifespan Extend

Discussion in 'Science and Technology' started by Matthew, May 15, 2012.

  1. Matthew
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    Matthew Blue dog all the way!

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    First Gene Therapy Successful Against Aging-Associated Decline: Mouse Lifespan Extended Up to 24% With a Single Treatment
    First gene therapy successful against aging-associated decline: Mouse lifespan extended up to 24% with a single treatment

    ScienceDaily (May 14, 2012) — A new study consisting of inducing cells to express telomerase, the enzyme which -- metaphorically -- slows down the biological clock -- was successful. The research provides a "proof-of-principle" that this "feasible and safe" approach can effectively "improve health span."


    A number of studies have shown that it is possible to lengthen the average life of individuals of many species, including mammals, by acting on specific genes. To date, however, this has meant altering the animals' genes permanently from the embryonic stage -- an approach impracticable in humans. Researchers at the Spanish National Cancer Research Centre (CNIO), led by its director María Blasco, have demonstrated that the mouse lifespan can be extended by the application in adult life of a single treatment acting directly on the animal's genes. And they have done so using gene therapy, a strategy never before employed to combat aging. The therapy has been found to be safe and effective in mice.

    Mice treated at the age of one lived longer by 24% on average, and those treated at the age of two, by 13%. The therapy, furthermore, produced an appreciable improvement in the animals' health, delaying the onset of age-*‐related diseases -- like osteoporosis and insulin resistance -- and achieving improved readings on aging indicators like neuromuscular coordination.
     
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  2. JimBowie1958
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    JimBowie1958 Old Fogey

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    That is very interesting. Have you seen this one?

    Chronic Buckyball Administration Doubles Rat Lifespan

    http://extremelongevity.net/wp-content/uploads/C60-Fullerene.pdf
    Once the first rat died, they stopped giving the rats the Buckeyball solution, so who knows how long they could have lived had they continued?
     
  3. waltky
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    waltky Wise ol' monkey Supporting Member

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    The researchers say that biological systems are "one of the coolest places for computing"...
    :cool:
    Rewritable DNA memory shown off
    22 May 2012 - The trick was to balance the effects of two competing proteins - integrase and excisionase
     
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  4. Matthew
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    Matthew Blue dog all the way!

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    I believe nearly everything is possible and the more we learn the more we won't know. That's a good reason to keep pushing forward!
     
  5. ShackledNation
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    ShackledNation Libertarian

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    Give me whatever that mouse is on while I'm still young!
     
  6. waltky
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    waltky Wise ol' monkey Supporting Member

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    Granny gonna get her bones tested an' she says if the doctor's cute she might let him jump her bones...
    :eek:
    Nasa team find 'new way' to spot osteoporosis
    28 May 2012 - For many people, breaking a bone is their first clue that they have the condition
     

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