Alzheimers reversed with skin cancer drug

[Truthmatters]

Vitals - Cancer drug reverses Alzheimer's in mice

 

[waltky]

Cancer drug clears dementia plaque in mice...

Alzheimer's brain plaques 'rapidly cleared' in mice
9 February 2012 - Destructive plaques found in the brains of Alzheimer's patients have been rapidly cleared by researchers testing a cancer drug on mice.

The US study, published in the journal Science, reported the plaques were broken down at "unprecedented" speed. Tests also showed an improvement in some brain function. Specialists said the results were promising, but warned that successful drugs in mice often failed to work in people. The exact cause of Alzheimer's remains unknown, but one of the leading theories involves the formation of clumps of a protein called beta-amyloid. These damage and kill brain cells, eventually resulting in memory problems and the inability to think clearly.

Clearing protein plaques is a major focus of Alzheimer's research and drugs are already being tested in human clinical trials. In the body, the role of removing beta-amyloid falls to apolipoprotein E - or ApoE. However, people have different versions of the protein. Having the ApoE4 genetic variant is one of the biggest risk factors for developing the disease.

Helping hand

Scientists at the Case Western Reserve University in Ohio were investigating ways of boosting levels of ApoE, which in theory should reduce levels of beta-amyloid. They tested bexarotene, which has been approved for use to treat cancers in the skin, on mice with an illness similar to Alzheimer's. After one dose in young mice, the levels of beta-amyloid in the brain were "rapidly lowered" within six hours and a 25% reduction was sustained for 70 hours.

In older mice with established amyloid plaques, seven days of treatment halved the number of plaques in the brain. The study said there were improvements in brain function after treatment, in nest building, maze performance and remembering electrical shocks. Researchers Paige Cramer said: "This is an unprecedented finding. Previously, the best existing treatment for Alzheimer's disease in mice required several months to reduce plaque in the brain."

In people?

The research is at a very early stage, and drugs often do not make the leap from animal experiment to human treatment. Fellow researcher Prof Gary Landreth said the study was "particularly exciting and rewarding" and held the "potential promise of a therapy for Alzheimer's disease". However, he stressed that the drug had been tested in only three "mouse models" which simulate the early stages of the disease and are not Alzheimer's.

More BBC News - Alzheimer's brain plaques 'rapidly cleared' in mice

 

[syrenn]

If its true and can be proven in human clinical trials.....

 

[Big Fitz]

Vitals - Cancer drug reverses Alzheimer's in mice

Awesome news if true!

 

[Ancient lion]

Bexarotene works by promoting the production of another protein, called Apolipoprotein E, which binds to and clears amyloid beta from the brain.

 

[strollingbones]

yall are aware that they have 'cured' mice of this before....

human trials will determine the use.....and i wonder how far gone a person can be and brought back?

so far there are no dosages etc....

 

[strollingbones]

and there is no profit in a cure. estimated cost...1,200 a month....and not covered by insurance

 

[Douger]

murkins. I gotta go jump start the Saeco for some espresso. It's chilly out this morning.
IOS Press - Journal Article

 

[Douger]

More fucking nonsense, likely having a Jew behind the curtain.
Caffeine inhaler sparks controversy - Yahoo! News

 

[waltky]

Slow walking link to dementia...

Slow walking 'predicts dementia'
15 February 2012 - Does walking speed say anything about health?

The speed someone walks may predict the likelihood of developing dementia later in life, according to researchers in the US. They also told a conference that grip strength in middle-age was linked to the chance of a stroke. The scientists said more studies were needed to understand what was happening. Experts said the findings raised important questions, but more research was needed. Suggestions of a link between slow walking speed and poor health have been made before.

A study, published in the British Medical Journal in 2009, said there was a "strong association" between slow walking speed and death from heart attacks and other heart problems. A Journal of the American Medical Association study suggested a link between walking faster over the age of 65 and a longer life. Dr Erica Camargo, who conducted the latest study at the Boston Medical Centre, said: "While frailty and lower physical performance in elderly people have been associated with an increased risk of dementia, we weren't sure until now how it impacted people of middle age." Brain scans, walking speed and grip strength were recorded for 2,410 people who were, on average, 62 years old.

Results presented at the Academy of Neurology's annual meeting said that 11 years later, 34 people had developed dementia and 79 had had a stroke. The researchers said slower walking speeds were linked to a higher risk of dementia and stronger grip with a lower risk of stroke. Dr Camargo said: "These are basic office tests which can provide insight into risk of dementia and stroke and can be easily performed by a neurologist or general practitioner. "Further research is needed to understand why this is happening and whether preclinical disease could cause slow walking and decreased strength." The findings have not yet, however, been published in a peer-reviewed academic journal.

Dr Marie Janson, director of development at Alzheimer's Research UK, said: "Although this study has yet to be published in full, it does raise some important questions about whether physical problems, such as difficulty walking, could precede other symptoms associated with dementia. "Further study could shed new insight into how walking speed and dementia may be linked." Dr Anne Corbett, research manager at the Alzheimer's Society, said: "Before people take stock in the strength of a handshake or the speed you cross the road, more research is needed to understand why and what other factors are involved. "The good news is that there are many things you can do to reduce your risk of developing dementia. "We recommend you eat a healthy balanced diet, don't smoke, maintain a healthy weight, take regular exercise; and get your blood pressure and cholesterol checked regularly."

The Stroke Association's Dr Sharlin Ahmed, said: "Around a third of those who have a stroke are left with some kind of physical disability, including hand weakness and difficulty walking. However, this is the first time we have seen research that looks at the presence of related symptoms before a stroke. "This is an interesting study, but a lot more research is needed before we can conclude that strength of grip or walking speed can determine the risk of stroke."

BBC News - Slow walking 'predicts dementia'

 

[Harry Dresden]

murkins. I gotta go jump start the Saeco for some espresso. It's chilly out this morning.
IOS Press - Journal Article

hey Gordo.....if you hate America so much why do you always show us Scientific studies coming out of America instead of Costa Rica?.....as a matter of fact.....you never show anything from your newly adopted land.....are they showing our old TV shows too?....

 

[waltky]

An Alzheimer's cure in time for the Baby Boomers?...

Antibody Therapy Clears Destructive Alzheimer’s Brain Plaques
December 07, 2012 - Scientists say they've developed a type of disease-fighting antibody that, in tests with laboratory mice, is able to clear away the destructive brain plaques, or protein deposits, believed to cause Alzheimer’s Disease. Researchers note that while several experimental drugs have shown promise in preventing plaque development, this new antibody therapy is the first to successfully remove existing plaques, suggesting a possible treatment for Alzheimer's patients.

By the time most people visit their doctors complaining of serious memory problems and cognitive decline, experts say their brains very likely are already riddled with sticky deposits of amyloid beta protein. These plaques are the hallmark of Alzheimer's, a progressive neurodegenerative disease that eventually leads to disability and death. According to Alzheimer’s Disease International, in 2010 there were an estimated 35.6 million people around the world suffering from various forms of dementia, including Alzheimer’s. Researchers at drug maker Eli Lilly report their experimental antibody therapy binds to and literally sweeps away existing plaques in a mouse model of Alzheimer’s. Their new antibody is part of a trend in so-called immunotherapy in which the body's immune system proteins, or antibodies, can be engineered to target and disable specific disease-causing molecules.

In Eli Lilly's neurodegenerative section, Ronald DeMattos works on new therapies to treat and prevent Alzheimer's disease. “What we’ve been able to demonstrate is that by treatment with this antibody that is very specific to binding to this deposited sticky material… we’re actually able to remove pre-existing clumps or plaque material,” he explained. In a healthy brain, the protein beta amyloid is normally broken down and eliminated by the body. But in people with Alzheimer’s, the dissolvable proteins accumulate and form hardened plaques. Researchers theorize that water-soluble beta amyloid washes over existing plaques, interfering with therapeutic attempts to eliminate the buildup.

Instead of genetically engineering a drug that targeted all of the beta amyloid in an experimental group of mice bred to have Alzheimer’s disease, DeMattos and colleagues developed an antibody that attached to and eliminated only the hardened plaque deposits. “The antibody is meant literally to enter the brain and help one’s own body facilitate the removal of this deposited plaque material. And it’s our hope that by doing so, we can hopefully mitigate some of the cognitive deficits that are attributed to the disease,” DeMattos said.

But it remains to be seen, DeMattos says, whether elimination of hardened Alzheimer’s plaques leads to memory improvements or stops the cognitive decline associated with the disease. Alzhiemer’s patients typically begin to develop beta amyloid deposits ten or more years before they are diagnosed, according to DeMattos, who says the ultimate goal would be to treat individuals before they develop signs of the disease. An article on a new antibody therapy for Alzheimer’s disease is published in the journal Neuron.

Source

 

[sealybobo]

An Alzheimer's cure in time for the Baby Boomers?...

Antibody Therapy Clears Destructive Alzheimer’s Brain Plaques
December 07, 2012 - Scientists say they've developed a type of disease-fighting antibody that, in tests with laboratory mice, is able to clear away the destructive brain plaques, or protein deposits, believed to cause Alzheimer’s Disease. Researchers note that while several experimental drugs have shown promise in preventing plaque development, this new antibody therapy is the first to successfully remove existing plaques, suggesting a possible treatment for Alzheimer's patients.

By the time most people visit their doctors complaining of serious memory problems and cognitive decline, experts say their brains very likely are already riddled with sticky deposits of amyloid beta protein. These plaques are the hallmark of Alzheimer's, a progressive neurodegenerative disease that eventually leads to disability and death. According to Alzheimer’s Disease International, in 2010 there were an estimated 35.6 million people around the world suffering from various forms of dementia, including Alzheimer’s. Researchers at drug maker Eli Lilly report their experimental antibody therapy binds to and literally sweeps away existing plaques in a mouse model of Alzheimer’s. Their new antibody is part of a trend in so-called immunotherapy in which the body's immune system proteins, or antibodies, can be engineered to target and disable specific disease-causing molecules.

In Eli Lilly's neurodegenerative section, Ronald DeMattos works on new therapies to treat and prevent Alzheimer's disease. “What we’ve been able to demonstrate is that by treatment with this antibody that is very specific to binding to this deposited sticky material… we’re actually able to remove pre-existing clumps or plaque material,” he explained. In a healthy brain, the protein beta amyloid is normally broken down and eliminated by the body. But in people with Alzheimer’s, the dissolvable proteins accumulate and form hardened plaques. Researchers theorize that water-soluble beta amyloid washes over existing plaques, interfering with therapeutic attempts to eliminate the buildup.

Instead of genetically engineering a drug that targeted all of the beta amyloid in an experimental group of mice bred to have Alzheimer’s disease, DeMattos and colleagues developed an antibody that attached to and eliminated only the hardened plaque deposits. “The antibody is meant literally to enter the brain and help one’s own body facilitate the removal of this deposited plaque material. And it’s our hope that by doing so, we can hopefully mitigate some of the cognitive deficits that are attributed to the disease,” DeMattos said.

But it remains to be seen, DeMattos says, whether elimination of hardened Alzheimer’s plaques leads to memory improvements or stops the cognitive decline associated with the disease. Alzhiemer’s patients typically begin to develop beta amyloid deposits ten or more years before they are diagnosed, according to DeMattos, who says the ultimate goal would be to treat individuals before they develop signs of the disease. An article on a new antibody therapy for Alzheimer’s disease is published in the journal Neuron.

Source

In the meantime I know this guy just called him Miele booboo. His mom is going through it right now. I have given her small doses of marijuana cookies and 2 times I thought I killed her. Today being one. My dad and I are not going to try it again because it's just not worth it but once she threw up because she was much more mellow so I think I just overdid it the two times. But it's just not worth it I'm not a doctor and I don't know what the proper dosage is. Plus obviously the cookie is upsetting to her stomach. So I think I'm going to ask the doctor what I can do to help ease the anxiety and that your is debility and the sadness and crying that I see her going through. I think if I knew how to properly those it would be a good thing but clearly I'm not doing it right. Or I mean my friends not doing it right

 

[waltky]

Repurposing Zerontin/ethosuximide may help with neurodegenerative diseases...

Anti-epileptic drug may help with neurodegenerative diseases
Oct. 13, 2015 - Researchers found Zerontin slowed the expression of genes that lead to the diseases.

Researchers have found the anti-epileptic drug ethosuximide can help protect against of certain neurodegenerative diseases in worm models, according to a new study. Neurodegeneration is the progressive loss of nerve structure and function that leads to diseases such as Parkinson's and Alzheimer's. "Incidence of these diseases is on the rise due to our increasingly aging population, yet there is a lack of effective therapies to treat them," said Alan Morgan, a professor of cellular and molecular physiology at the University of Liverpool, in a press release.

Repurposing the drug for the conditions may lead to the development of new treatments for them.​

Researchers found that ethosuximide, sold as Zarontin, slowed or stopped the expression of mutant genes in worms similar to the human genes that cause dementia. "Our research suggests that ethosuximide has potential for repurposing as a treatment for multiple neurodegenerative diseases and provides a platform from which new medicines could be developed," Morgan said. The researchers plan to test the efficacy of the drug with mice to confirm its effects. The study is published in Molecular Neurodegeneration.

Anti-epileptic drug may help with neurodegenerative diseases - UPI.com

 

[Delta4Embassy]

I actually look fowards to dementia and other brain issues with old age. Think I want to be clear-headed when facing my imminent death? Hell no. Wanna be befuddled and thinking God and Heaven are real.

 

[sealybobo]

I actually look fowards to dementia and other brain issues with old age. Think I want to be clear-headed when facing my imminent death? Hell no. Wanna be befuddled and thinking God and Heaven are real.

You don't want Alzheimers. My mom is going through it. No, actually my entire family is going through it. My dad is in hell and my entire family is heartbroken. And every once in awhile my mom has a moment of clarity and realizes the hell she is in. She's a zombie and she knows it. Can't talk, can't do NOTHING.

 

[JimBowie1958]

I actually look fowards to dementia and other brain issues with old age. Think I want to be clear-headed when facing my imminent death? Hell no. Wanna be befuddled and thinking God and Heaven are real.

You sure you're not already pretty befuddled already?

 

[sealybobo]

Vitals - Cancer drug reverses Alzheimer's in mice

August 2016, mom just died from complications due to Alzheimer's. I am so proud of me and my dad for taking care of her as long as we possibly could. I was taking her for walks a month ago and she was still swallowing ground up food. As soon as she couldn't walk anymore my dad could no longer do it so we put her in a home. $11,000 a month. Eventually she stopped eating or drinking and she only lasted 3 weeks.

She needed calm down pills because she was going insane but the trade off is it makes them zombies and that contributed to her death too. But if I was going insane like that, please drug me. And morphine probably helped put her out of her misery.

My dad and I agree we hope they come up with a cure ASAP but we will be pissed too if it happens in our lifetime.

 

[hadit]

Vitals - Cancer drug reverses Alzheimer's in mice

August 2016, mom just died from complications due to Alzheimer's. I am so proud of me and my dad for taking care of her as long as we possibly could. I was taking her for walks a month ago and she was still swallowing ground up food. As soon as she couldn't walk anymore my dad could no longer do it so we put her in a home. $11,000 a month. Eventually she stopped eating or drinking and she only lasted 3 weeks.

She needed calm down pills because she was going insane but the trade off is it makes them zombies and that contributed to her death too. But if I was going insane like that, please drug me. And morphine probably helped put her out of her misery.

My dad and I agree we hope they come up with a cure ASAP but we will be pissed too if it happens in our lifetime.

I am sorry for your loss. My mother is also degenerating, slowly but surely. Dad is taking good care of her, but she's already stated emphatically that if he dies before her, she's going straight into the nursing home (they already live in a house on the grounds of the home). Thankfully, other than Mom's Alzheimer's, they're both doing remarkably well at 80.

 

[sealybobo]

Vitals - Cancer drug reverses Alzheimer's in mice

August 2016, mom just died from complications due to Alzheimer's. I am so proud of me and my dad for taking care of her as long as we possibly could. I was taking her for walks a month ago and she was still swallowing ground up food. As soon as she couldn't walk anymore my dad could no longer do it so we put her in a home. $11,000 a month. Eventually she stopped eating or drinking and she only lasted 3 weeks.

She needed calm down pills because she was going insane but the trade off is it makes them zombies and that contributed to her death too. But if I was going insane like that, please drug me. And morphine probably helped put her out of her misery.

My dad and I agree we hope they come up with a cure ASAP but we will be pissed too if it happens in our lifetime.

I am sorry for your loss. My mother is also degenerating, slowly but surely. Dad is taking good care of her, but she's already stated emphatically that if he dies before her, she's going straight into the nursing home (they already live in a house on the grounds of the home). Thankfully, other than Mom's Alzheimer's, they're both doing remarkably well at 80.

My mom was 69. Too young huh? God bless you and your family. Only we know what you are going through. People who haven't dealt with it don't have a clue. It's wearing on your dad too i bet but if hes like my dad hed rather have her around than not.

I asked him if instead of her being sick for 5 years would he have rather had 5 good years and then lose her suddenly and he says lose her suddenly would have been worse. But that's not true. Of course he would have rather had 5 good years instead of what we went thru.

But one things for sure we definitely got to say goodbye